Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease

PS Bernstein, B Li, PP Vachali, A Gorusupudi… - Progress in retinal and …, 2016 - Elsevier
The human macula uniquely concentrates three carotenoids: lutein, zeaxanthin, and meso-
zeaxanthin. Lutein and zeaxanthin must be obtained from dietary sources such as green …

[HTML][HTML] Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition

LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Total body irradiation or chemotherapy conditioning in childhood ALL: a multinational, randomized, noninferiority phase III study

C Peters, JH Dalle, F Locatelli, U Poetschger… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Total body irradiation (TBI) before allogeneic hematopoietic stem cell
transplantation (HSCT) in pediatric patients with acute lymphoblastic leukemia (ALL) is …

Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

D Sheehan, G Meade, VM Foley… - Biochemical journal, 2001 - portlandpress.com
The glutathione transferases (GSTs; also known as glutathione S-transferases) are major
phase II detoxification enzymes found mainly in the cytosol. In addition to their role in …

Glutathione transferases, regulators of cellular metabolism and physiology

PG Board, D Menon - Biochimica et biophysica acta (bba)-general subjects, 2013 - Elsevier
BACKGROUND: The cytosolic glutathione transferases (GSTs) comprise a super family of
proteins that can be categorized into multiple classes with a mixture of highly specific and …

The role of glutathione in cancer

GK Balendiran, R Dabur… - Cell Biochemistry and …, 2004 - Wiley Online Library
Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is
highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It …

Glutathione S-transferase polymorphisms and their biological consequences

JD Hayes, RC Strange - Pharmacology, 2000 - karger.com
Two supergene families encode proteins with glutathione S-transferase (GST) activity: the
family of soluble enzymes comprises at least 16 genes; the separate family of microsomal …

[HTML][HTML] Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death

E Laborde - Cell death & differentiation, 2010 - nature.com
Glutathione transferases (GSTs) are enzymes that catalyze the conjugation of glutathione
(GSH) to a variety of electrophilic substances. Their best known role is as cell housekeepers …

Concise review of the glutathione S-transferase and their significance to toxicology.

DL Eaton, TK Bammler - Toxicological sciences, 1999 - search.ebscohost.com
The article discusses the major features of the glutathione S-transferases (GST), a multi-
gene family of enzymes involved in the detoxification or activation of a wide variety of …

NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses

M García-Closas, N Malats, D Silverman, M Dosemeci… - The Lancet, 2005 - thelancet.com
Background Many reported associations between common genetic polymorphisms and
complex diseases have not been confirmed in subsequent studies. An exception could be …