Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …

Haematopoiesis in the bone marrow (BM) maintains blood and immune cell production
throughout postnatal life. Haematopoiesis first emerges in human BM at 11–12 weeks after …

Although it is clear that trisomy 21 causes Down syndrome, the molecular events acting
downstream of the trisomy remain ill defined. Using complementary genomics analyses, we …

Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition
to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a …

From the bestselling author, Barbara J. Bain, the new edition of this practical reference on
the principles of leukaemia diagnosis and classification has been fully updated, and …

Abstract Germline SAMD9 and SAMD9L mutations cause a spectrum of multisystem
disorders that carry a markedly increased risk of developing myeloid malignancies with …

The key differences between tumors arising in children and those in adults stem from the
cellular origin of cancer at different ages, with adult cancers arising within aging cell …

Introduction: Historically, the majority of childhood cancers, including acute lymphoblastic
leukemia (ALL), were not thought to have a hereditary basis. However, recent germline …

INTRODUCTION Leukemia is the most common cancer in children, with the first genetic
alterations often occurring during fetal development. These initiating events generate …