It has been one and a half centuries since Enrico Sertoli published the seminal discovery of
the testicular 'nurse cell', not only a key cell in the testis, but indeed one of the most amazing …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Metabolism of neoplastic cells is shifted toward high glucose uptake and enhanced lactate
production. Lactate dehydrogenase (LDH), which is comprised of two major subunits, LDH-A …

Metabolomic analysis has proven to be a useful tool in biomarker discovery and the
molecular classification of cancers. In order to find new biomarkers, and to better understand …

Sertoli cells (SCs) provide structural and nutritional support for developing germ cells.
Normal glucose metabolism of SCs is necessary for spermatogenesis. Melatonin could …

Physiology and metabolism are often sexually dimorphic, but the underlying mechanisms
remain incompletely understood. Here, we use the intestine of Drosophila melanogaster to …

Sertoli cells play a pivotal role in the complex spermatogenesis process. This study aimed to
investigate the effects of PM 2.5 on Sertoli cells using the TM4 cell line and a real time whole …

The consumption of energy-dense diets has contributed to an increase in the prevalence of
obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often …

Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …

Cancer cells present a particular metabolic behavior. We hypothesized that the progression
of bladder cancer could be accompanied by changes in cells glycolytic profile. We studied …