Acinetobacter baumannii Antibiotic Resistance Mechanisms

I Kyriakidis, E Vasileiou, ZD Pana, A Tragiannidis - Pathogens, 2021 - mdpi.com
Acinetobacter baumannii is a Gram-negative ESKAPE microorganism that poses a threat to
public health by causing severe and invasive (mostly nosocomial) infections linked with high …

Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals

S Ibrahim, N Al-Saryi, IMS Al-Kadmy, SN Aziz - Molecular biology reports, 2021 - Springer
Acinetobacter baumannii has become a major concern for scientific attention due to
extensive antimicrobial resistance. This resistance causes an increase in mortality rate …

Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical Reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Interplay between β-lactamases and new β-lactamase inhibitors

K Bush, PA Bradford - Nature Reviews Microbiology, 2019 - nature.com
Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …

The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace

LK Logan, RA Weinstein - The Journal of infectious diseases, 2017 - academic.oup.com
Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

Emergence, molecular mechanisms and global spread of carbapenem-resistant Acinetobacter baumannii

M Hamidian, SJ Nigro - Microbial genomics, 2019 - microbiologyresearch.org
Acinetobacter baumannii is a nosocomial pathogen that has emerged as a global threat
because of high levels of resistance to many antibiotics, particularly those considered to be …

Epidemiology and mechanisms of resistance of extensively drug resistant Gram-negative bacteria

EM Eichenberger, JT Thaden - Antibiotics, 2019 - mdpi.com
Antibiotic resistance has increased markedly in gram-negative bacteria over the last two
decades, and in many cases has been associated with increased mortality and healthcare …

The global ascendency of OXA-48-type carbapenemases

JDD Pitout, G Peirano, MM Kock… - Clinical microbiology …, 2019 - Am Soc Microbiol
Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: mechanisms and epidemiology

A Potron, L Poirel, P Nordmann - International journal of antimicrobial …, 2015 - Elsevier
Multidrug resistance is quite common among non-fermenting Gram-negative rods, in
particular among clinically relevant species including Pseudomonas aeruginosa and …

[HTML][HTML] The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide

P Nordmann, L Poirel - Clinical Microbiology and Infection, 2014 - Elsevier
The spread of carbapenemase producers in Enterobacteriaceae has now been identified
worldwide. Three main carbapenemases have been reported; they belong to three classes …