Background Antibiotic use is largely under-regulated in Egypt leading to the emergence of
resistant isolates. Carbapenems are last resort agents to treat Acinetobacter baumannii …

Despite 70 years of clinical use, β-lactam antibiotics still remain at the forefront of
antimicrobial chemotherapy. The major challenge to these life-saving therapeutics is the …

The aim of this study was to investigate the prevalence of ESBL and MBL encoding genes
among A. baumannii isolates. In this cross sectional study, 100 A. baumannii strains were …

Antimicrobials are commonly used in conventional livestock production and manure is
widely applied to agricultural lands as fertilizer. This practice raises questions regarding the …

Antimicrobial resistance in hospital and community-onset bacterial infections is a significant
source of patient morbidity and mortality. In the past decade, we have witnessed the …

The oxa23 gene encoding the OXA-23 carbapenemase (and several minor variants of it) is
widespread in Acinetobacter baumannii clinical isolates and compromises treatment with …

Avibactam, a non-β-lactam β-lactamase inhibitor with activity against extended-spectrum β-
lactamases (ESBLs), KPC, AmpC, and some OXA enzymes, extends the antibacterial activity …

This review deeply addresses for the first time the diversity, regulation and mechanisms
leading to mutational overexpression of intrinsic β-lactamases from non-fermenting and …

Horizontal gene transfer (HGT) is a driving force to the evolution of bacteria. The fast
emergence of antimicrobial resistance reflects the ability of genetic adaptation of pathogens …

Carbapenemase producing Gram-negative pathogen is of great concern for physician. The
challenging aspects are treatment option and infection control. Monitoring of respective …