[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

[HTML][HTML] Curcumin: Biological activities and modern pharmaceutical forms

M Urošević, L Nikolić, I Gajić, V Nikolić, A Dinić… - Antibiotics, 2022 - mdpi.com
Curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-hepta-1, 6-diene-3, 5-dione) is a natural
lipophilic polyphenol that exhibits significant pharmacological effects in vitro and in vivo …

Nano-curcumin therapy, a promising method in modulating inflammatory cytokines in COVID-19 patients

H Valizadeh, S Abdolmohammadi-Vahid… - International …, 2020 - Elsevier
Background As an ongoing worldwide health issue, Coronavirus disease 2019 (COVID–19)
has been causing serious complications, including pneumonia, acute respiratory distress …

[HTML][HTML] Improving curcumin bioavailability: Current strategies and future perspectives

R Tabanelli, S Brogi, V Calderone - Pharmaceutics, 2021 - mdpi.com
Curcumin possesses a plethora of interesting pharmacological effects. Unfortunately, it is
also characterized by problematic drug delivery and scarce bioavailability, representing the …

[HTML][HTML] Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: a review

SJ Stohs, O Chen, SD Ray, J Ji, LR Bucci, HG Preuss - Molecules, 2020 - mdpi.com
Curcumin exerts a wide range of beneficial physiological and pharmacological activities,
including antioxidant, anti-amyloid, anti-inflammatory, anti-microbial, anti-neoplastic …

[HTML][HTML] Anti-obesity effects of polyphenol intake: Current status and future possibilities

M Boccellino, S D'Angelo - International journal of molecular sciences, 2020 - mdpi.com
The prevalence of obesity has steadily increased worldwide over the past three decades.
The conventional approaches to prevent or treat this syndrome and its associated …

[HTML][HTML] Neuroprotective activities of curcumin in Parkinson's disease: A review of the literature

EE Nebrisi - International journal of molecular sciences, 2021 - mdpi.com
Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting
dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized …

[HTML][HTML] Curcumin-based nanoformulations: A promising adjuvant towards cancer treatment

S Hafez Ghoran, A Calcaterra, M Abbasi, F Taktaz… - Molecules, 2022 - mdpi.com
Throughout the United States, cancer remains the second leading cause of death.
Traditional treatments induce significant medical toxic effects and unpleasant adverse …

[HTML][HTML] The effects of curcumin on diabetes mellitus: a systematic review

LT Marton, SM Barbalho - Frontiers in endocrinology, 2021 - frontiersin.org
Diabetes mellitus (DM) is an ensemble of metabolic conditions that have reached pandemic
proportions worldwide. Pathology's multifactorial nature makes patient management …

A triple‐blind, placebo‐controlled, randomized clinical trial to evaluate the effect of curcumin‐containing nanomicelles on cellular immune responses subtypes and …

M Hassaniazad, E Eftekhar… - Phytotherapy …, 2021 - Wiley Online Library
In COVID‐19 patients, cytokine storm due to excessive immune responses can cause
severe complications. In this study, we investigated the effect of curcumin nanomicelles on …