The protein Klotho can significantly delay aging, so it has attracted widespread attention.
Abnormal downregulation of Klotho has been detected in several aging-related diseases …

Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron
numbers and function and leading to end-stage renal disease and mineral disorders …

Vascular calcification (VC) is regarded as a common feature of vascular aging. Klotho
deficiency reportedly contributes to VC, which can be ameliorated by restoration of Klotho …

Abstract Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity
and mortality in advanced CKD. The major pathological changes of CKD-associated CVD …

Depression is a serious neuropsychiatric disease affecting an increasing number of people
worldwide. Cognitive deficits (including inattention, poor memory, and decision-making …

衰老是人类疾病的主要危险因素, 延缓衰老已成为提高生活质量的紧迫问题.
其中血管衰老贯穿于年龄相关疾病(如2 型糖尿病, 神经退行性疾病, 动脉粥样硬化, 高血压) …

Klotho was first discovered as an anti-ageing protein linked to a number of age-related
disease processes, including cardiovascular, renal, musculoskeletal, and …

Background and aims Abdominal aortic calcification (AAC) has been recognized as an
independent predictor of cardiovascular disease (CVD) incidence and mortality. The aim of …

Degenerative changes of the retinal pigment epithelium (RPE) triggered by transforming
growth factor-β2 (TGF-β2) and oxidative stress play a critical role in the progression of age …

FoxOs and their post-translational modification by phosphorylation, acetylation, and
methylation can affect epigenetic modifications and promote the expression of downstream …