Sleep plays a vital role in brain function and systemic physiology across many body
systems. Problems with sleep are widely prevalent and include deficits in quantity and …

Objectives Chronic pain, with or without an identified diagnosis or cause, is widespread and
commonly associated with sleep disturbances. However, research has often used poor …

Sleep disturbances and chronic pain are considered public health concerns. They are
frequently associated, and the direction of its relationship and possible mechanisms …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

The present study pooled the prevalence of sleep disturbances and depression in
community-dwelling older adults (mean age≥ 60 years) and quantified the strength of …

Physical, mental, and social well-being are part of the concept of health according to the
World Health Organization, in addition to the absence of disease and infirmity. Therefore, for …

Sleep–wake disturbances following traumatic brain injury (TBI) are increasingly recognized
as a serious consequence following injury and as a barrier to recovery. Injury-induced sleep …

Patients with CP often present to clinicians with numerous medical and psychological
comorbidities, including mood and anxiety disorders, secondary medical problems related to …

The relationship between pain and depression is thought to be bidirectional and the
underlying neurobiology 'shared'between the two conditions. However, these claims are …

Objective Sharp increases in opioid prescriptions, and associated increases in overdose
deaths in the 2000s, evoked widespread calls to change perceptions of opioid analgesics …