Role of gut microbiota, immune imbalance, and allostatic load in the occurrence and development of diabetic kidney disease

YZ Han, HJ Zheng, BX Du, Y Zhang… - Journal of Diabetes …, 2023 - Wiley Online Library
Diabetic kidney disease (DKD) is a prevailing complication arising from diabetes mellitus.
Unfortunately, there are no trustworthy and efficacious treatment modalities currently …

Shuangshen Ningxin capsule alleviates myocardial ischemia–reperfusion injury in miniature pigs by modulating mitophagy: network pharmacology and experiments …

F Jia, Y Chen, G Xin, L Li, Z Liu, S Xu, J Gao, H Meng… - Chinese Medicine, 2023 - Springer
Background Myocardial ischemia/reperfusion injury (MI/RI) is involved in a variety of
pathological states for which there is no effective treatment exists. Shuangshen Ningxin …

Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes

S Weawsiangsang, N Rattanachak… - International Journal of …, 2023 - mdpi.com
Hydroquinine has antimicrobial potential with demonstrated activity against several bacteria,
including multidrug-resistant (MDR) P. aeruginosa reference strains. Despite this, there is …

Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models

L Duan, Z Hao, R Ji, X Li, H Wang, Y Su, F Guan… - International Journal of …, 2024 - Elsevier
Alzheimer's disease (AD) is a chronic neurodegenerative disease with high prevalence,
long duration and poor prognosis. The blood-brain barrier (BBB) is a physiologic barrier in …

B. glomerulata Promotes Neuroprotection Against Ischemic Stroke by Inhibiting Apoptosis through the Activation of PI3K/AKT/mTOR Pathway

Z Xu, Y Li, P Pi, Y Yi, H Tang, Z Zhang, H Xiong, B Lei… - Phytomedicine, 2024 - Elsevier
Abstract Background: Brassaiopsis glomerulata (Blum) Regel (B. glomerulata) is recognized
as a traditional Chinese medicine (TCM) primarily used for promoting blood circulation and …

Discovery of a novel homoisoflavonoid derivative 5g for anti-osteoclastic bone loss via targeting FGFR1

Z Chen, AM Encarnacion, RPS Rajan, H Yao… - European Journal of …, 2024 - Elsevier
Several flavonoids have been shown to exert anti-osteoporosis activity. However, the
structure-activity relationship and the mechanism of anti-osteoporosis activity of flavonoids …

A peptide from yak ameliorates hypoxia-induced kidney injury by inhibiting inflammation and apoptosis via Nrf2 pathway

F Yang, Z Chu, Q Wu, G Qu, Z He, J An, Y Tang, S Sun… - Food Bioscience, 2024 - Elsevier
Chronic kidney disease is a prevalent and severe significant complication of hypoxia. This
study found that peptide LVYPFPGPIPN could protect hypoxia-induced renal injury in the …

PPARG and the PTEN‐PI3K/AKT Signaling Axis May Cofunction in Promoting Chemosensitivity in Hypopharyngeal Squamous Cell Carcinoma

B Han, J Chen, S Chen, X Shen, L Hou, J Fang… - PPAR …, 2024 - Wiley Online Library
It has been demonstrated that PPARG may interact with the PTEN‐PI3K/AKT pathway,
contributing to its involvement in the chemotherapy treatment of hypopharyngeal squamous …

Anti-osteoporosis effect of Mori Follum-Portulaca oleracea L.-Lycium barbarum L. extract based on network pharmacology and experimental validation and its …

M Jia, X Yang, Y Bao, J Huo - Food Bioscience, 2024 - Elsevier
Abstract In China, Mori Follum, Portulaca oleracea L., and Lycium barbarum L. are
traditional Chinese medicine and food used in treating osteoporosis. However, the active …

Study on the Chemical Composition and Blood-Entry Components of Nourishing Blood Diuretic Formula Based on Liquid Chromatography-Mass Spectrometry and …

SC Yang, X Lei, SF Xie, J Huang… - Natural Product …, 2024 - journals.sagepub.com
Objective: Analyzing the chemical composition and blood-entry components of Nourishing
Blood Diuretic Formula (NBDF) by Liquid Chromatography-Mass Spectrometry (LC-MS) …