Schizophrenia remains a major burden on patients and society. The dopamine hypothesis
attempts to explain the pathogenic mechanisms of the disorder, and the …

Administration of noncompetitive NMDA/glutamate receptor antagonists, such as
phencyclidine (PCP) and ketamine, to humans induces a broad range of schizophrenic-like …

Research in the last decade has unveiled a crucial role for the trillions of microorganisms
that reside in the gut in influencing host neurodevelopment across the lifespan via the …

Animal modeling has been instrumental in dissecting pathophysiological mechanisms and
designing more effective therapies in many areas of medicine but not so in psychiatry. The …

Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …

Since the first mention of fetal programming of adult health and disease, a plethora of
programming events in early life has been suggested. These have included intrauterine and …

Caesarean section and instrumental delivery rates are increasing in many parts of the world
for a range of cultural and medical reasons, with limited consideration as to how 'mode of …

Current research into schizophrenia has remained highly fragmented, much like the clinical
presentation of the disease itself. Differing theories as to the cause and progression of …

Altered subcortical dopaminergic activity is thought to be involved in the pathophysiology of
several disorders including schizophrenia, substance abuse and attention deficit …

A disruption in normal brain development has been hypothesized to contribute to the
aetiology of major psychiatric disorders. According to the 'double-hit'hypothesis, mutant …