Osteoporosis is a serious health issue among aging postmenopausal women. The majority
of postmenopausal women with osteoporosis have bone loss related to estrogen deficiency …

Since chronic inflammation can be seen in severe, long-lasting diseases such as cancer,
there is a high demand for effective methods to modulate inflammatory responses. Among …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

Periodontitis involves the loss of connective tissue attachment and alveolar bone. Single cell
RNA-seq experiments have provided new insight into how resident cells and infiltrating …

Ageing is a complex process, induced by multifaceted interaction of genetic, epigenetic, and
environmental factors. It is manifested by a decline in the physiological functions of …

Osteoarthritis (OA) was once defined as a non-inflammatory arthropathy, but it is now well-
recognized that there is a major inflammatory component to this disease. In addition to …

One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein
response (UPR), are triggered by the accumulation of unfolded and misfolded proteins …

In this study, for the first time we discovered that the M1/M2 macrophage phenotype ratio is
increased in bone marrow of ovariectomized (OVX) osteoporotic C57BL/6 mice. Considering …

Osteoporosis bone defect is a refractory orthopaedic disease which characterized by
impaired bone quality and bone regeneration capacity. Current therapies, including …