[PDF][PDF] Exosomes as mediators of intercellular crosstalk in metabolism

R Isaac, FCG Reis, W Ying, JM Olefsky - Cell metabolism, 2021 - cell.com
Exosomes are nanoparticles secreted by all cell types and are a large component of the
broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted …

Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges

M Nemati, B Singh, RA Mir, M Nemati, A Babaei… - Cell Communication and …, 2022 - Springer
Background Many eukaryote cells produce membrane-enclosed extracellular vesicles (EVs)
to establish cell-to-cell communication. Plant-derived EVs (P-EVs) contain proteins, RNAs …

Exosome detection via the ultrafast-isolation system: EXODUS

Y Chen, Q Zhu, L Cheng, Y Wang, M Li, Q Yang, L Hu… - Nature …, 2021 - nature.com
Exosomes have shown great potential in disease diagnostics and therapeutics. However,
current isolation approaches are burdensome and suffer from low speed, yield and purity …

Zeta potential of extracellular vesicles: toward understanding the attributes that determine colloidal stability

G Midekessa, K Godakumara, J Ord, J Viil… - ACS …, 2020 - ACS Publications
Extracellular vesicles (EVs), including exosomes and microvesicles (< 200 nm), play a vital
role in intercellular communication and carry a net negative surface charge under …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small …

KS Visan, RJ Lobb, S Ham, LG Lima… - Journal of …, 2022 - Wiley Online Library
Small extracellular vesicles (sEVs) provide major promise for advances in cancer
diagnostics, prognostics, and therapeutics, ascribed to their distinctive cargo reflective of …

[HTML][HTML] Extracellular vesicles: The next generation in gene therapy delivery

R Cecchin, Z Troyer, K Witwer, KV Morris - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are esteemed as a promising delivery vehicle for various genetic
therapeutics. They are relatively inert, non-immunogenic, biodegradable, and …

[HTML][HTML] Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer

H Wang, Z Lu, X Zhao - Journal of hematology & oncology, 2019 - Springer
Hepatocellular carcinoma (HCC, also called primary liver cancer) is one of the most fatal
cancers in the world. Due to the insidiousness of the onset of HCC and the lack of effective …