Innate immune activation in neurodegenerative diseases
S Castro-Gomez, MT Heneka - Immunity, 2024 - cell.com
Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …
APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread
A recent case report described an individual who was a homozygous carrier of the APOE3
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …
Christchurch (APOE3ch) mutation and resistant to autosomal dominant Alzheimer's Disease …
[HTML][HTML] Artificial intelligence for drug discovery and development in Alzheimer's disease
The complex molecular mechanism and pathophysiology of Alzheimer's disease (AD) limits
the development of effective therapeutics or prevention strategies. Artificial Intelligence (AI) …
the development of effective therapeutics or prevention strategies. Artificial Intelligence (AI) …
Association of Chronic Pain with Biomarkers of Neurodegeneration, Microglial Activation, and Inflammation in Cerebrospinal Fluid and Impaired Cognitive Function
A Sadlon, P Takousis, B Ankli… - Annals of …, 2024 - Wiley Online Library
Objective Debate surrounds the role of chronic pain as a risk factor for cognitive decline and
dementia. This study aimed at examining the association of chronic pain with biomarkers of …
dementia. This study aimed at examining the association of chronic pain with biomarkers of …
Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease
S Jiang, G Cai, Z Yang, H Shi, H Zeng, Q Ye, Z Hu… - ACS …, 2024 - ACS Publications
The association between dysfunctional microglia and amyloid-β (Aβ) is a fundamental
pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the …
pathological event and increases the speed of Alzheimer's disease (AD). Additionally, the …
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model
Microglia help limit the progression of Alzheimer's disease (AD) by constraining amyloid-β
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
(Aβ) pathology, effected through a balance of activating and inhibitory intracellular signals …
Peripheral GFAP and NfL as early biomarkers for dementia: longitudinal insights from the UK Biobank
X Wang, Z Shi, Y Qiu, D Sun, H Zhou - BMC medicine, 2024 - Springer
Background Peripheral glial fibrillary acidic protein (GFAP) and neurofilament light chain
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …
(NfL) are sensitive markers of neuroinflammation and neuronal damage. Previous studies …
Cryo-EM structures of Aβ40 filaments from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid angiopathy
We used electron cryo-microscopy (cryo-EM) to determine the structures of Aβ40 filaments
from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid …
from the leptomeninges of individuals with Alzheimer's disease and cerebral amyloid …
Adaptive immune changes associate with clinical progression of Alzheimer's disease
Background Alzheimer's disease (AD) is the most frequent cause of dementia. Recent
evidence suggests the involvement of peripheral immune cells in the disease, but the …
evidence suggests the involvement of peripheral immune cells in the disease, but the …
Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease
M Dicarlo, P Pignataro, C Zecca… - Annals of …, 2024 - Wiley Online Library
Objective Irisin, released by muscles during exercise, was recently identified as a
neuroprotective factor in mouse models of Alzheimer disease (AD). In a cohort of AD …
neuroprotective factor in mouse models of Alzheimer disease (AD). In a cohort of AD …