Colorectal cancer (CRC) is a malignant tumor in the digestive system whose incidence and
mortality is high-ranking among tumors worldwide. The initiation and progression of CRC is …

Colorectal cancer (CRC) is a global health problem responsible for 10% of all cancer
incidences and 9.4% of all cancer deaths worldwide. The number of new cases increases …

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …

Abstract Rationale: Tumor-associated macrophages (TAMs), generally displaying the pro-
tumor M2-like phenotype, strongly influence the progression of colorectal cancer (CRC) via …

Colorectal cancer (CRC) affects 1 in 23 males and 1 in 25 females, making it the third most
common cancer. With roughly 608000 deaths worldwide, CRC accounts for 8% of all cancer …

PD-1 (Programmed Cell Death Protein-1) and PD-L1 (Programmed Cell Death Ligand-1)
play a crucial role in regulating the immune system and preventing autoimmunity. Cancer …

Colorectal cancer (CRC) is the third most frequently occurring tumor in the human
population. CRCs are usually adenocarcinomatous and originate as a polyp on the inner …

Inducing lysosomal dysfunction is emerging as a promising means for cancer therapy.
Agrocybe cylindracea fucoglucogalactan (ACP) is a bioactive ingredient with anti-tumor …

Colorectal cancer (CRC) is a disease with complex pathogenesis, it is prone to metastasis,
and its development involves abnormalities in multiple signaling pathways. Surgery …

The tumor microenvironment is overwhelmingly dictated by macrophages, intimately
affiliated with tumors, exercising pivotal roles in multiple processes, including angiogenesis …