Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

Ubiquitylation and deubiquitylation are reversible protein post-translational modification
(PTM) processes involving the regulation of protein degradation under physiological …

Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes,
and the enzymes involved are tightly regulated by multiple factors including posttranslational …

Ubiquitylation plays multiple roles not only in proteasome-mediated protein degradation but
also in various other cellular processes including DNA repair, signal transduction, and …

Eukaryotic proteomes are enormously sophisticated through versatile post-translational
modifications (PTMs) of proteins. A large variety of code generated via PTMs of proteins by …

Osteoporosis is an ageing‐related disease, that has become a major public health problem
and its pathogenesis has not yet been fully elucidated. Substantial evidence suggests a …

Parkinson's disease (PD) is a common neurodegenerative disease that is mainly in middle-
aged people and elderly people, and the pathogenesis of PD is complex and diverse. The …

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease associated with the
central nervous system (CNS). Autoimmunity is caused by an abnormal immune response to …

Type 1 diabetes (T1D) is a chronic disease caused by the selective destruction of the insulin-
producing pancreatic beta cells by infiltrating immune cells. We presently evaluated the …