Peripheral artery disease (PAD) is a major health problem with increased cardiovascular
mortality, morbidity and disabling critical limb threatening ischemia (CLTI) and amputation …

Various therapeutic effects have been found for alkaloids. However, severe side effects can
limit the clinical applications of these bioactive compounds. Colchicine alkaloid as an anti …

Colchicine is widely used to treat gouty arthritis for years. Previous studies showed that
colchicine overdose can cause liver damage, yet the mechanism underlying its …

The role of cholesterol, mainly low-density lipoproteins (LDL-C), as a causal risk factor for
atherosclerotic cardiovascular disease (ASCVD) is now established and accepted by the …

Platelets are one of the coagulation cells. When platelet activation occurs, many mediators
are released and affect endothelial cells (ECs) and lead to endothelial dysfunction (ED). ED …

Ischemic cardiovascular disease and stroke remain the leading cause of global morbidity
and mortality. While aging, protective mechanisms in the body gradually deteriorate …

Introduction Chronic coronary syndrome (CCS) remains the leading cause of death
worldwide with high admission/re-admission rates. Medical databases were searched on …

Introduction Surgery is a risk factor for flares in people with gout. However, gout flares after
endovascular interventional procedures are not well understood. The aim of this study was …