Growing evidence suggests that the gut microbiome (GM) plays a critical role in health and
disease. However, the contribution of GM to psychiatric disorders, especially anxiety …

Background: To date, the pathogenesis of gastric cancer (GC) remains unclear. We
combined public database resources and bioinformatics analysis methods, explored some …

Mouse models are an essential tool in different areas of research, including nutrition and
phytochemical research. Traditional inbred mouse models have allowed the discovery of …

Increasing evidence has shown that thirdhand smoke (THS) exposure is likely to induce
adverse health effects. An important knowledge gap remains in our understanding of THS …

Objective Animal studies remain essential for understanding mechanisms of epilepsy and
identifying new therapeutic targets. However, existing animal models of epilepsy do not …

The interindividual variability and sexual dimorphisms in the development of nonalcoholic
fatty liver disease (NAFLD) are still poorly understood. In the present study, male and female …

Abstract The Collaborative Cross (CC) and the Diversity Outbred (DO) stock mouse panels
are the most powerful murine genetics tools available to the genetics community. Together …

Background & Aims Activity of nuclear factor κB transcription factors and signaling via signal
transducer and activator of transcription (STAT) are frequently altered in gastric cancer cells …

The laboratory mouse has served for decades as an informative animal model system for
investigating the genetic and genomic basis of cancer in humans. Although thousands of …

Immune checkpoint inhibitors (ICI) have improved outcomes for a variety of malignancies;
however, many patients fail to benefit. While tumor-intrinsic mechanisms are likely involved …