Effect of solvation on the molecular structure, vibrational assignment, nature of bonding, and the antiviral drug-like potential of troxerutin against HBV proteins
Drugs used in the management of Hepatitis B virus (HBV) infection are largely based on
nucleosides or their analogues and these have several side-effects. These drugs only inhibit …
nucleosides or their analogues and these have several side-effects. These drugs only inhibit …
[HTML][HTML] Heavy metal co-resistance with antibiotics amongst bacteria isolates from an open dumpsite soil
Heavy metal co-resistance with antibiotics appears to be synergistic in bacterial isolates via
similar mechanisms. This synergy has the potential to amplify antibiotics resistance genes in …
similar mechanisms. This synergy has the potential to amplify antibiotics resistance genes in …
Spectral (FT-IR, NMR, UV) characterization, DFT studies, and molecular docking of hydrazine derivatives as antiviral agent for yellow fever (YFV)
Yellow fever virus continues to break out and claim lives in Africa and South America despite
the availability of a vaccine. Furthermore, there are reports of neurological and multiorgan …
the availability of a vaccine. Furthermore, there are reports of neurological and multiorgan …
[HTML][HTML] Antimicrobial analysis of honey against Staphylococcus aureus isolates from wound, ADMET properties of its bioactive compounds and in-silico evaluation …
Background One of the main challenges of wound healing is infection with multi-drug
resistant (MDR) bacteria such as Staphylococcus aureus. The spectrum of antibiotics used …
resistant (MDR) bacteria such as Staphylococcus aureus. The spectrum of antibiotics used …
[HTML][HTML] Betulinic and ursolic acids from Nauclea latifolia roots mediate their antimalarial activities through docking with PfEMP-1 and PfPKG proteins
Abstract Background Chemotherapies target the PfEMP-1 and PfPKG proteins in
Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the …
Plasmodium falciparum, the parasite that causes malaria, in an effort to prevent the …
Antimalarial activity of Mangifera indica aqueous extract in Plasmodium berghei's apicoplast
Purpose: To investigate the in vivo antiplasmodial effect of Mangifera indica aqueous extract
in Plasmodium berghei-infected mice, and to characterize its phytochemical constituents …
in Plasmodium berghei-infected mice, and to characterize its phytochemical constituents …
[HTML][HTML] In-silico evaluation of bioactive compounds from selected medicinal plants from Southern Nigeria against hepatitis C virus genotype 1 RNA-directed RNA …
Background At the moment, there is no vaccine for the hepatitis C virus (HCV), despite it
being more infectious than the hepatitis B virus (HBV) and the human immunodeficiency …
being more infectious than the hepatitis B virus (HBV) and the human immunodeficiency …
In-silico assessment of bioactive compounds from chewing stick (Salvadora persica) against N-acetylneuraminate lyase (5ZKA) of Fusobacterium nucleatum involved …
Background Fusobacterium nucleatum is implicated in the formation of subgingival dental
plaques. The main therapy of choice is the use of non-surgical periodontal therapy; …
plaques. The main therapy of choice is the use of non-surgical periodontal therapy; …
Spice-Induced Metal Contamination and Microbiological Risk Assessment of Instant Noodles Prepared for Human Consumption
With the rising worries of potential metal contamination in cooked noodles, this study aimed
at unravelling, for the first time, the possible source of metal contamination in cooked …
at unravelling, for the first time, the possible source of metal contamination in cooked …
[HTML][HTML] Impacts of sunlight exposure on physicochemical parameters, potential toxic metals, and microbial characteristics of sachet drinking water sold in Calabar …
Poor handling of potable water is a well-known route of contamination. Despite this,
Nigeria's most consumed packaged potable water called “sachet” or “pure water” is still …
Nigeria's most consumed packaged potable water called “sachet” or “pure water” is still …