Autophagy is the cellular process by which proteins, macromolecules, and organelles are
targeted to and degraded by the lysosome. Given that neurodegenerative diseases involve …

Protein misfolding leads to the formation of aggregated proteins and protein inclusions,
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …

As the world's population ages, neurodegenerative disorders are poised to become the
commonest cause of death. Despite this, they remain essentially untreatable. Characterized …

Competing models exist in the literature for the relationship between mutant Huntingtin exon
1 (Httex1) inclusion formation and toxicity. In one, inclusions are adaptive by sequestering …

Aging is a natural process accompanied by a progressive accumulation of damage in all
constituent macromolecules (nucleic acids, lipids and proteins). Accumulation of damage in …

The proteasome controls the concentrations of most proteins in eukaryotic cells. It
recognizes its protein substrates through ubiquitin tags and initiates degradation at …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a polyglutamine expansion mutation in the huntingtin protein. Expansions above 40 …

Huntington's disease is caused by expansion of a polyglutamine (polyQ) domain within exon
1 of the huntingtin gene (Httex1). The prevailing hypothesis is that the monomeric Httex1 …

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, Creutzfeldt–Jacob,
Huntington's diseases and amyotrophic lateral sclerosis, are mainly characterized by the …

Huntington's Disease (HD) is a hereditary neurodegenerative disorder caused by the
expansion of a CAG triplet repeat in the HTT gene, resulting in the production of an aberrant …