Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …

Analysis of nanomaterial biocoronas in biological and environmental surroundings

P Zhang, M Cao, AJ Chetwynd, K Faserl… - Nature …, 2024 - nature.com
A biomolecular coating, or biocorona, forms on the surface of engineered nanomaterials
(ENMs) immediately as they enter biological or environmental systems, defining their …

The landscape of gold nanocrystal surface chemistry

KM Greskovich, KM Powderly… - Accounts of chemical …, 2023 - ACS Publications
Conspectus Gold nanoparticles (AuNPs) exhibit unique size-and shape-dependent
properties not obtainable at the macroscale. Gold nanorods (AuNRs), with their morphology …

Biofluid specific protein coronas affect lipid nanoparticle behavior in vitro

D van Straten, H Sork, L van de Schepop… - Journal of Controlled …, 2024 - Elsevier
Lipid nanoparticles (LNPs) have successfully entered the clinic for the delivery of mRNA-and
siRNA-based therapeutics, most recently as vaccines for COVID-19. Nevertheless, there is a …

Concentration and composition of the protein corona as a function of incubation time and serum concentration: an automated approach to the protein corona

KM Poulsen, CK Payne - Analytical and Bioanalytical Chemistry, 2022 - Springer
Nanoparticles in contact with proteins form a “corona” of proteins adsorbed on the
nanoparticle surface. Subsequent biological responses are then mediated by the adsorbed …

In situ characterization techniques of protein corona around nanomaterials

F Fu, D Crespy, K Landfester, S Jiang - Chemical Society Reviews, 2024 - pubs.rsc.org
Nanoparticles (NPs) inevitably interact with proteins upon exposure to biological fluids,
leading to the formation of an adsorption layer known as the “protein corona”. This corona …

Biomolecular Corona of Gold Nanoparticles: The Urgent Need for Strong Roots to Grow Strong Branches

L Boselli, V Castagnola, A Armirotti, F Benfenati… - Small, 2024 - Wiley Online Library
Gold nanoparticles (GNPs) are largely employed in diagnostics/biosensors and are among
the most investigated nanomaterials in biology/medicine. However, few GNPbased …

Gold-iron oxide (Au/Fe3O4) magnetic nanoparticles as the nanoplatform for binding of bioactive molecules through self-assembly

ECHT Lau, M Åhlén, O Cheung, AY Ganin… - Frontiers in Molecular …, 2023 - frontiersin.org
Nanomedicine plays a crucial role in the development of next-generation therapies. The use
of nanoparticles as drug delivery platforms has become a major area of research in …

Adsorption and Molecular Display of a Redox-Active Protein on Gold Nanoparticle Surfaces

KNL Hoang, CJ Murphy - Langmuir, 2023 - ACS Publications
Engineered gold nanoparticles (AuNPs) have great potential in many applications due to
their tunable optical properties, facile synthesis, and surface functionalization via thiol …

[HTML][HTML] Unveiling the challenges of engineered protein corona from the proteins' perspective

C Marques, G Borchard, O Jordan - International Journal of Pharmaceutics, 2024 - Elsevier
It is well known that protein corona affects the “biological identity” of nanoparticles (NPs),
which has been seen as both a challenge and an opportunity. Approaches have moved from …