Monogenic diabetes: what it teaches us on the common forms of type 1 and type 2 diabetes
Y Yang, L Chan - Endocrine reviews, 2016 - academic.oup.com
To date, more than 30 genes have been linked to monogenic diabetes. Candidate gene and
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
genome-wide association studies have identified> 50 susceptibility loci for common type 1 …
[HTML][HTML] NeuroD: the predicted and the surprising
JH Chae, GH Stein, JE Lee - Molecules and cells, 2004 - Elsevier
NeuroD (otherwise known as BETA2) is a basic helixloop-helix (bHLH) transcription factor
that is capable of converting embryonic epidermal cells into fully differentiated neurons in …
that is capable of converting embryonic epidermal cells into fully differentiated neurons in …
[HTML][HTML] Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development
Photoreceptor development of the vertebrate visual system is controlled by a complex
transcription regulatory network. OTX2 is expressed in the mitotic retinal progenitor cells …
transcription regulatory network. OTX2 is expressed in the mitotic retinal progenitor cells …
Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data
GC Mannino, G Sesti - Molecular diagnosis & therapy, 2012 - Springer
Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, abnormally elevated
hepatic glucose production, and reduced glucose-stimulated insulin secretion. Treatment …
hepatic glucose production, and reduced glucose-stimulated insulin secretion. Treatment …
Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion
K Chu, MJ Tsai - Diabetes, 2005 - Am Diabetes Assoc
BETA2 (NeuroD1) is a member of the basic helix-loop-helix transcription factor family.
BETA2 plays an important role in the development of the pancreas and the nervous system …
BETA2 plays an important role in the development of the pancreas and the nervous system …
[HTML][HTML] A homozygous missense mutation in NEUROD1 is associated with nonsyndromic autosomal recessive retinitis pigmentosa
Purpose.: Mutations in the same gene can lead to different clinical phenotypes. In this study,
we aim to identify novel genotype–phenotype correlations and novel disease genes by …
we aim to identify novel genotype–phenotype correlations and novel disease genes by …
Neuronal Differentiation 1 gene Ala45Thr polymorphism and type 2 diabetes mellitus: A meta-analysis of 7,940 subjects
YY Li, H Wang, YY Zhang - Nutrition, Metabolism and Cardiovascular …, 2021 - Elsevier
Background and aims Previous studies have shown that there was a possible relationship
between human Neuronal Differentiation 1 (NEUROD1) gene Ala45Thr polymorphism and …
between human Neuronal Differentiation 1 (NEUROD1) gene Ala45Thr polymorphism and …
NeuroD1 A45T and PAX4 R121W polymorphisms are associated with plasma glucose level of repaglinide monotherapy in Chinese patients with type 2 diabetes
ZC Gong, Q Huang, XP Dai, GH Lei… - British journal of …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Repaglinide is an insulin
secretagogue agent widely used in the treatment of type 2 diabetes mellitus (T2DM) …
secretagogue agent widely used in the treatment of type 2 diabetes mellitus (T2DM) …
[HTML][HTML] Identification of gene mutations associated with type 1 diabetes by next-generation sequencing in affected Palestinian families
A Bawatneh, A Darwish, H Eideh, HM Darwish - Frontiers in Genetics, 2024 - frontiersin.org
Introduction: Diabetes Mellitus is a group of metabolic disorders characterized by
hyperglycemia secondary to insulin resistance or deficiency. It is considered a major health …
hyperglycemia secondary to insulin resistance or deficiency. It is considered a major health …
[HTML][HTML] Identification of gene mutations associated with type 1 diabetes by next-generation sequencing in affected Palestinian families
A Bawatneh, A Darwish, H Eideh, HM Darwish - Frontiers in Genetics, 2024 - frontiersin.org
Introduction: Diabetes Mellitus is a group of metabolic disorders characterized by
hyperglycemia secondary to insulin resistance or deficiency. It is considered a major health …
hyperglycemia secondary to insulin resistance or deficiency. It is considered a major health …