The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …

Background Alzheimer's disease (AD) is the most common type of dementia, affecting one in
eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown …

Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and
experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked …

Neurodegenerative diseases such as Alzheimer's disease have proven resistant to new
treatments. The complexity of neurodegenerative disease mechanisms can be highlighted …

Progranulin (PGRN) is implicated in Alzheimer's disease (AD) as well as frontotemporal
lobar degeneration. Genetic studies demonstrate an association of the common GRN …

Long‐term or severe lack of protective factors is important in the pathogenesis of
neurodegenerative dementia. Progranulin (PGRN), a neurotrophic factor expressed mainly …

Deficient progranulin levels cause dose-dependent neurological syndromes:
haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and nullizygosity …

Transactivation response DNA binding protein 43 kDa (TDP-43) and tau are major
pathological proteins of neurodegenerative disorders, of which neuronal and glial …

Progranulin (PGRN) is a protein encoded by the GRN gene with multiple identified functions
including as a neurotrophic factor, tumorigenic growth factor, anti-inflammatory cytokine and …