The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It
is comprised of membrane-attached proteoglycans, glycosaminoglycan chains …

Sepsis is a multifactorial syndrome primarily determined by the host response to an invading
pathogen. It is common, with over 48 million cases worldwide in 2017, and often lethal. The …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the so-called
coronavirus disease (COVID-19), which is characterized by a broad spectrum of clinical …

Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Beyond haemostasis, platelets have emerged as versatile effectors of the immune response.
The contribution of platelets in inflammation, tissue integrity and defence against infections …

Acute vascular endothelial dysfunction is a central event in the pathogenesis of sepsis,
increasing vascular permeability, promoting activation of the coagulation cascade, tissue …

We propose a framework for understanding and interpreting the pathophysiology of Myalgic
Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) that considers wider determinants …

The endothelium is the largest organ in the body and recent studies have shown that the
endothelial glycocalyx (eGCX) plays a major role in health and disease states. The integrity …

The glycocalyx comprises glycosylated proteins and lipids and fcorms the outermost layer of
cells. It is involved in fundamental inter-and intracellular processes, including non-self-cell …

The glycocalyx surrounds every eukaryotic cell and is a complex mesh of proteins and
carbohydrates. It consists of proteoglycans with glycosaminoglycan side chains, which are …