Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule
implicated in many central and benefic molecular pathways and has a well-established role …

Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

Highly sensitive and high‐accuracy detection of biomolecular changes is vital for the early
diagnosis and treatment of diverse diseases. Due to their unique advantages and the broad …

Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive
impairment, memory loss, and behavioral deficits. β-amyloid1–42 (Aβ1–42) aggregation is a …

Alzheimer's disease (AD) is a leading cause of death and disability among older adults.
Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes …

Glial ion transporters are important in regulation of ionic homeostasis, cell volume, and
cellular signal transduction under physiological conditions of the central nervous system …

Background Soluble aggregates of oligomeric forms of tau protein (oTau) have been
associated with impairment of synaptic plasticity and memory in Alzheimer's disease …

The placenta plays a vital role in fetal development during pregnancy. Dysfunction of the
placenta can be caused by oxidative stress and can lead to abnormal fetal development …

Introduction: The postmortem examination still represents the reference standard for
detecting the pathological nature of chronic neurodegenerative diseases (NDD). This …