Role of inflammatory cells in airway remodeling in COPD

Y Wang, J Xu, Y Meng, IM Adcock… - International journal of …, 2018 - Taylor & Francis
COPD is characterized by chronic bronchitis, chronic airway obstruction, and emphysema,
leading to a progressive and irreversible decline in lung function. Inflammation is central for …

Pirfenidone: molecular mechanisms and potential clinical applications in lung disease

SM Ruwanpura, BJ Thomas… - American journal of …, 2020 - atsjournals.org
Pirfenidone (PFD) is a pharmacological compound with therapeutic efficacy in idiopathic
pulmonary fibrosis. It has been chiefly characterized as an antifibrotic agent, although it was …

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments

L Zuo, F He, GG Sergakis… - … of Physiology-Lung …, 2014 - journals.physiology.org
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders
such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading …

Molecular and cellular mechanisms responsible for beneficial effects of mesenchymal stem cell‐derived product “exo‐d‐MAPPS” in attenuation of chronic airway …

CR Harrell, D Miloradovic, R Sadikot… - Analytical Cellular …, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs), due to their potential for differentiation into alveolar
epithelial cells and their immunosuppressive characteristics, are considered a new …

Pulmonary disease in HIV-infected adults in the era of antiretroviral therapy

ME Fitzpatrick, KM Kunisaki, A Morris - Aids, 2018 - journals.lww.com
HIV in the antiretroviral therapy era is characterized by multimorbidity and the frequent
occurrence of HIV-associated non-AIDS chronic health conditions. Respiratory symptoms …

The immune response in adipocytes and their susceptibility to infection: a possible relationship with infectobesity

O López-Ortega, NC Moreno-Corona… - International Journal of …, 2022 - mdpi.com
The current obesity pandemic has been expanding in both developing and developed
countries. This suggests that the factors contributing to this condition need to be …

Single-cell immunophenotyping revealed the association of CD4+ central and CD4+ effector memory T cells linking exacerbating chronic obstructive pulmonary …

N Gémes, JÁ Balog, P Neuperger, E Schlegl… - Frontiers in …, 2023 - frontiersin.org
Introduction Tobacco smoking generates airway inflammation in chronic obstructive
pulmonary disease (COPD), and its involvement in the development of lung cancer is still …

Imbalance of peripheral blood T h17 and T reg responses in patients with chronic obstructive pulmonary disease

H Wang, H Ying, S Wang, X Gu, Y Weng… - The clinical …, 2015 - Wiley Online Library
Background Autoimmune responses mediated by cluster of differentiation 4+ T cells may
contribute to the development of chronic obstructive pulmonary disease (COPD). However …

Imbalance of Th17/Treg cells in mice with chronic cigarette smoke exposure

H Wang, W Peng, Y Weng, H Ying, H Li, D Xia… - International …, 2012 - Elsevier
BACKGROUND: Recent studies have revealed that autoimmune responses mediated by
CD4+ T cells may contribute to the development of chronic obstructive pulmonary disease …

Central role of T helper 17 cells in chronic hypoxia-induced pulmonary hypertension

LD Maston, DT Jones… - … of Physiology-Lung …, 2017 - journals.physiology.org
Inflammation is a prominent pathological feature in pulmonary arterial hypertension, as
demonstrated by pulmonary vascular infiltration of inflammatory cells, including T and B …