Current evidence suggests that activation of glial and immune cells leads to increased
production of proinflammatory mediators, creating a neuroinflammatory state …

The innate immune response represents the first-line of defense against invading
pathogens. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) have been …

Introduction The last decade has led to rapid developments and increased usage of
computational tools at the single-cell level. However, our knowledge remains limited in how …

Macrophages play key roles in tissue homeostasis, defense, disease, and repair.
Macrophages are highly plastic and exhibit distinct functional phenotypes based on micro …

Severe infection can lead to sepsis. In sepsis, the host mounts an inappropriately large
inflammatory response in an attempt to clear the invading pathogen. This sustained high …

Filamentous fungi have potential as an alternative protein source for use in aquafeeds due
to their high protein content and bioactive components. Paecilomyces variotii (PEKILO® …

Background: The inflammatory response in diabetes is strongly correlated with increasing
amounts of advanced glycation end products (AGEs), methylglyoxal (MGO), aldosterone …

Background: Macrophages and microglia play critical roles after spinal cord injury (SCI), with
the pro-healing, anti-inflammatory (M2) subtype being implicated in tissue repair. We …

Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

The natural periosteum is responsible for supporting bone homeostasis and initiating repair,
but is often damaged during bone fracture, causing acute inflammation and loss of a …