FMS-like tyrosine kinase 3 (FLT3) is a receptor tyrosine kinase that is expressed almost
exclusively in the hematopoietic compartment. Its ligand, FLT3 ligand (FL), induces …

Introduction. Colorectal cancer (CRC) is an important cause of morbidity and mortality
worldwide. Angiogenesis was reported as one important mechanism activated in colorectal …

Decrypting the dynamics of receptor dimerization on cell membranes bears great
importance in identifying the mechanisms regulating diverse cellular activities. In this regard …

Receptor tyrosine kinases (RTKs) play important roles in cell growth, motility, differentiation,
and survival. These single-pass membrane proteins are grouped into subfamilies based on …

The MARTINI coarse-grained model is used to gain insight into the association of WALP23
helices in three different lipid membranes: DMPC, DPPC and DOPC. Potentials of mean …

Interaction between transmembrane helices often determines biological activity of
membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers …

Förster resonance energy transfer (FRET) experiments are often used to study interactions
between integral membrane proteins in cellular membranes. However, in addition to the …

The human epidermal growth factor receptor (EGFR) of HER/ErbB receptor tyrosine kinase
family mediates a broad spectrum of cellular responses transducing biochemical signals via …

FRET is an indispensable experimental tool for studying membrane proteins. Currently, two
models are available for researchers to determine the oligomerization state of membrane …

Fibroblast growth factor receptor 3 (FGFR3) transduces biochemical signals via lateral
dimerization in the plasma membrane, and plays an important role in human development …