Extracellular vesicles have emerged as prominent regulators of the immune response
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …

Tumors often show, compared to normal tissues, a markedly decreased extracellular pH
resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …

Background Initially identified as a molecule that regulates the final step of glycolysis, the M2
isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the …

One key to malignant progression of pancreatic cancer (PC) is the acquired ability of tumour
cells to escape immune-mediated lysis. Hypoxic microenvironment plays a causal role in PC …

Pancreatic cancer is one of the common malignant tumors of the digestive system and is
known as the “king of cancers”. It is extremely difficult to diagnose at an early stage, the …

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC),
contributing to early metastasis and poor patient survival. Compared to the localized tumors …

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers and is the third
highest among cancer related deaths. Despite modest success with therapy such as …

Pancreatic cancer (PC) is a devastating disease, offering poor mortality rates for patients.
The current challenge being faced is the inability to diagnose patients in a timely manner …

Accurate diagnosis of tumors and predicting the therapeutic responses are highly
demanded in the clinic to improve the treatment efficacy and survival rates. Since hypoxia …