The tumour microenvironment (TME) strongly influences tumorigenesis and metastasis. Two
of the most characterized properties of the TME are acidosis and hypoxia, both of which are …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and difficult to treat
cancers with tumors typically exhibiting high levels of chronic hypoxia. Hypoxia activates …

Highlights•A novel in vitro platform for pancreatic cancer drug discovery is
suggested.•Design parameters for a pancreatic tumour-like construct are …

In solid tumors, the development of vasculature is, to some extent, slower than the
proliferation of the different types of cells that form the tissue, both cancer and stroma cells …

Herein, we found that salidroside suppressed hypoxia‐inducible factor 1 alpha (HIF‐1α) and
lysyl oxidase‐like protein 2 (LOXL2) within human pancreatic cancer BxPC‐3 cells cultured …

Pancreatic ductal adenocarcinoma (PDAC) is characterised by dense desmoplasia and
hypoxic microenvironment. Our previous reports demonstrated that hyaluronan (HA) …

Pancreatic cancer poses a significant challenge within the field of oncology due to its
aggressive behaviour, limited treatment choices, and unfavourable outlook. With a mere …

Hypoxia is a pathogenic characteristic of solid tumors owing to absent or abnormal
vasculature in the tumor microenvironment and essential in tumor progression …

Simple Summary Pancreatic cancer is characterized by a dense network of connective
tissue surrounding clusters of cancer cells, the so-called stroma. This ubiquitous connective …

As a significant contributor to cancer-related death, pancreatic cancer, as a recalcitrant
tumor, generally has an appalling prognosis that has not altered over many years. At the …