Initiation and development of cancer depend on multiple factors that mutations in genes and
epigenetic level can be considered as important drivers. Epigenetic factors include a large …

H19 is a long non-coding RNA [lncRNA] which was firstly described as an oncofetal
transcript. The imprinted gene is normally expressed from the maternal allele. However, this …

MicroRNA (miRNA) plays an important role in the occurrence, development, diagnosis and
treatment of diseases. More and more researchers begin to pay attention to the relationship …

Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth,
and early metastasis. The clinical outcomes of LC patients are generally poor due to the …

Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription
factors, responsible for regulating cellular proliferation, cellular differentiation, migration …

Background: Recently, increasing evidence has uncovered the roles of mRNA-miRNA-
lncRNA network in multiple human cancers. However, a systematic mRNA-miRNA-lncRNA …

Currently, resistance to tyrosine kinase inhibitors, such as gefitinib, has become one major
obstacle for improving the clinical outcome of patients with metastatic and advanced‑stage …

Resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such
as gefitinib, has greatly affected clinical outcomes in non-small cell lung cancer (NSCLC) …

The advent of deep sequencing technologies led to the identification of a considerable
amount of noncoding RNA transcripts, which are increasingly recognized for their functions …

Lung cancer remains one of the most common malignancies in the world. Nowadays, the
most common lung cancer is non-small cell lung cancer (NSCLC), namely …