Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …

Sarcopenic obesity, or the loss of muscle mass and function associated with excess
adiposity, is a largely untreatable medical condition associated with diminished quality of life …

The restriction of calories, branched-chain amino acids, and methionine have all been
shown to extend lifespan in model organisms. Recently, glycine was shown to significantly …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

The older population is increasing worldwide, and life expectancy is continuously rising,
predominantly thanks to medical and technological progress. Healthspan refers to the …

Cognitive decline frequently occurs with increasing age, but mechanisms contributing to age-
associated cognitive decline (ACD) are not well understood and solutions are lacking …

N-acetylcysteine (NAC) is used as a sports supplement for its ability to modulate exercise-
induced oxidative damage through its antioxidant actions and maintenance of glutathione …

Aortic aneurysm and dissection are complicated diseases having both high prevalence and
mortality. It is usually diagnosed at advanced stages and posing diagnostic and therapeutic …

N-acetylcysteine (NAC), a precursor of cysteine and, thereby, glutathione (GSH), acts as an
antioxidant through a variety of mechanisms, including oxidant scavenging, GSH …

Metabolism plays an important role in regulating aging at several levels, and metabolic
reprogramming is the main driving force of aging. Due to the different metabolic needs of …