Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

NAD+ and its derivatives NADH, NADP+, and NADPH are essential cofactors in redox
reactions and electron transport pathways. NAD serves also as substrate for an extensive …

Increasing evidence has indicated the roles of sirtuin 7 (SIRT7) in numerous human
cancers. However, the effects and the clinical significance of SIRT7 in human lung cancer is …

Abstract Objective Sirtuin-7 (SIRT7) is a class III histone deacetylase that plays an important
role in cancer development and frequently overexpressed in carcinomas. In this study, the …

The morbidity and mortality rates of nonsmall‐cell lung cancer (NSCLC) have increased in
recent years. We aimed to explore the biological role of fibroblast growth factor 5 (FGF5) in …

Epithelial–mesenchymal transition (EMT), a physiological process during embryogenesis,
can become pathological in the presence of different driving forces. Reduced oxygen …

The NAD+-dependent deacetylase SIRT7 is a pivotal regulator of DNA damage response
(DDR) and a promising drug target for developing cancer therapeutics. However, limited …

Abstract “Exterior-interior correlation between the lung and large intestine” is one of the
important contents of traditional Chinese medicine. This theory describes the role of the lung …

Summary Sirtuin 7 (SIRT7) is a NAD+ (nicotinamide adenine dinucleotide) dependent
deacetylase that is reported to contribute to tumour growth and invasion by selectively acting …