COVID-19, transmitted by SARS-CoV-2, is one of the most serious pandemic situations in
the history of mankind, and has already infected a huge population across the globe. This …

Owing to the propensity of anticoagulated patients to bleed, a strategy for reversal of
anticoagulation induced by any of the common agents is essential. Many patients are …

New drugs introduced to the market every year represent privileged structures for particular
biological targets. These new chemical entities (NCEs) provide insight into molecular …

Abstract Human factor Xa (FXa) is a serine protease of the common coagulation pathway.
FXa is known to activate prothrombin to thrombin, which eventually leads to the formation of …

Direct oral anticoagulants (DOACs) are first-line drugs used for the treatment of venous
thromboembolism and prevention of stroke in patients with atrial fibrillation. These drugs do …

Venous thromboembolism (VTE) is a prevalent yet preventable cause of death, particularly
among hospitalized patients. Studies have shown that the risk of VTE remains high for up to …

Background: The thrombin generation (TG) test is useful for characterizing global
hemostasis potential, but fluorescence substrate artifacts, such as thrombin …

Heparin-based delivery systems have been explored to improve their therapeutic efficacy
and to reduce toxicity for different administration routes. Regardless of the applied drug …

Heparin-based delivery systems have been explored to improve their therapeutic efficacy
and to reduce toxicity for different administration routes. Regardless of the applied drug …

The research contained within this thesis submitted for the degree of Doctor of Philosophy in
Medicine investigates the role of e-learning in improving knowledge mastery around venous …