[HTML][HTML] Repetitive restricted behaviors in autism spectrum disorder: from mechanism to development of therapeutics
J Tian, X Gao, L Yang - Frontiers in neuroscience, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized
by deficits in social communication, social interaction, and repetitive restricted behaviors …
by deficits in social communication, social interaction, and repetitive restricted behaviors …
[HTML][HTML] PARP-1: a critical regulator in radioprotection and radiotherapy-mechanisms, challenges, and therapeutic opportunities
WH Li, F Wang, GY Song, QH Yu, RP Du… - Frontiers in …, 2023 - frontiersin.org
Background: Since its discovery, poly (ADP-ribose) polymerase 1 (PARP-1) has been
extensively studied due to its regulatory role in numerous biologically crucial pathways …
extensively studied due to its regulatory role in numerous biologically crucial pathways …
[HTML][HTML] Aberrant IL-17 levels in rodent models of autism Spectrum disorder: a systematic review
AJ Thawley, LP Veneziani… - Frontiers in …, 2022 - frontiersin.org
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder
characterised by stereotyped behaviours, specific interests, and impaired communication …
characterised by stereotyped behaviours, specific interests, and impaired communication …
[HTML][HTML] Poly (ADP-Ribose) Polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities
X Xu, B Sun, C Zhao - Neurobiology of Disease, 2023 - Elsevier
Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
of the PARP superfamily, with its primary function being the facilitation of DNA damage …
[HTML][HTML] Neuroprotective Effects of PARP Inhibitors in Drosophila Models of Alzheimer's Disease
A Maggiore, AM Casale, W Toscanelli, U Cappucci… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is an irreversible age-related neurodegenerative disorder
clinically characterized by severe memory impairment, language deficits and cognitive …
clinically characterized by severe memory impairment, language deficits and cognitive …
MAP kinase inhibitor PD98059 regulates Th1, Th9, Th17, and natural T regulatory cells in an experimental autoimmune encephalomyelitis mouse model of multiple …
Experimental autoimmune encephalitis (EAE), an animal model of multiple sclerosis (MS),
provides significant insights into the mechanisms that initiate and drive autoimmunity. MS is …
provides significant insights into the mechanisms that initiate and drive autoimmunity. MS is …
[HTML][HTML] Emerging roles of T helper cells in non-infectious neuroinflammation: savior or sinner
CD4+ T cells, also known as T helper (Th) cells, contribute to the adaptive immunity both in
the periphery and in the central nervous system (CNS). At least seven subsets of Th cells …
the periphery and in the central nervous system (CNS). At least seven subsets of Th cells …
CXCR2 antagonist SB332235 mitigates deficits in social behavior and dysregulation of Th1/Th22 and T regulatory cell-related transcription factor signaling in male …
Autism spectrum disorders is a complex neurodevelopmental disorder characterized by
abnormal social interaction, defective communication, repetitive and stereotyped patterns of …
abnormal social interaction, defective communication, repetitive and stereotyped patterns of …
[PDF][PDF] Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice
Duplication and haploinsufficiency of the USP7 gene are implicated in autism spectrum
disorders (ASD), but the role for USP7 in neurodevelopment and contribution to ASD …
disorders (ASD), but the role for USP7 in neurodevelopment and contribution to ASD …
[HTML][HTML] Quantitative Determination of 5-Aminoisoquinoline, a PARP-1 Inhibitor by UPLC-MS/MS: In Silico ADME Profile and In Vitro Metabolic Stability Study
5-Aminoisoquinoline (5-AIQ) is a water-soluble, potent and selective Poly (ADP-ribose)
polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to …
polymerase 1 (PARP-1) inhibitor, widely used as a biochemical and pharmacological tool to …