A high number of genome variants are associated with complex traits, mainly due to genome-
wide association studies (GWAS). Using polygenic risk scores (PRSs) is a widely accepted …

Impulsivity is related to a host of mental and behavioral problems. It is a complex construct
with many different manifestations, most of which are heritable. The genetic compositions of …

Individual differences in self-control predict many health and life outcomes. Building on twin
literature, we used genomic structural equation modeling to test the hypothesis that genetic …

BackgroundDual-systems models, positing an interaction between two distinct and
competing systems (ie top-down self-control, and bottom-up reward-or emotion-based …

Individuals suffering from chronic pain develop substance use disorders (SUDs) more often
than others. Understanding the shared genetic influences underlying the comorbidity …

Sensation seeking is bidirectionally associated with levels of alcohol consumption in both
adult and adolescent samples, and shared neurobiological and genetic influences may in …

Background: Difficulty with self-control, or the ability to alter impulses and behavior in a goal-
directed way, predicts interpersonal conflict, lower socioeconomic attainments, and more …

Progress in the molecular genetic study of AUD and related phenotypes is being made.
Nonetheless, significant efforts are needed to conduct GWAS of more specific AUD risk …

We characterized the genetic architecture of the attention-deficit hyperactivity disorder-
substance use disorder (ADHD-SUD) relationship by investigating genetic correlation …

Aims This study uses a high-resolution phenome-wide approach to evaluate the
motivational mechanisms of polygenic risk scores (PRSs) that have been robustly …