Pain contributes substantially to reduced quality of life in individuals living with hidradenitis
suppurativa (HS). Although improved understanding of HS pathogenesis and treatment has …

Neuropathic pain is pain that arises as a direct consequence of a lesion or diseases
affecting the somatosensory system. Treatments for neuropathic pain include …

Noxious stimuli are detected by peripheral nociceptors and then transmitted to higher CNS
centers, where they are perceived as an unpleasant sensation. The mechanisms that govern …

Background: Neuropathic pain is an incurable disease which is defined as a chronic pain
caused by a disease or lesion of the nervous systems. Current treatments can provide a long …

The discovery and synthesis of a new series of pyrimidines as potent sigma-1 receptor (σ1R)
antagonists, associated with pharmacological antineuropathic pain activity, are the focus of …

Interventional pain management (IPM) options for refractory neuropathic pain (NP) have
recently increased with availability of peripheral nerve stimulation (PNS) equipment and …

The literature reveals that neuropathic pain is underdiagnosed and often undertreated or
treated with ineffective or untested modalities. Evolving definitions of neuropathic pain has …

Introduction 3. Characteristics of neuropathic pain 4. Characteristics of glia 5. Role of glia in
neuropathic pain 5.1. Neuropathic pain induced by glia activation 5.1. 1. Role of microglia in …

By use of the 6-hydroxypyridazinone framework, a new series of potent σ1 receptor ligands
associated with pharmacological antineuropathic pain activity was synthesized and is …

The emerging role of microRNAs (miRNAs) have been deeply explored in multiple diseases
including neuropathic pain. miR‐194 was widely reported to be a tumor suppressor and was …