Pain can be both a cause and a consequence of sleep deficiency. This bidirectional
relationship between sleep and pain has important implications for clinical management of …

Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Importance Fibromyalgia is present in as much as 2% to 8% of the population, is
characterized by widespread pain, and is often accompanied by fatigue, memory problems …

Ample evidence suggests that sleep and pain are related. However, many questions remain
about the direction of causality in their association, as well as mechanisms that may account …

Pain is a manifestation of rheumatoid arthritis (RA) that is mediated by inflammatory and non-
inflammatory mechanisms and negatively affects quality of life. Recent findings from a Phase …

Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

Objective Radiographic measures of the pathologic changes of knee osteoarthritis (OA)
have shown modest associations with clinical pain. We sought to evaluate possible …

Background and objective Central sensitization (CS) is a phenomenon associated with
several medical diagnoses, including postcancer pain, low back pain, osteoarthritis …

Epidemiological, cross-sectional, and prospective studies suggest that insomnia, chronic
pain, and depression frequently co-occur and are mutually interacting conditions. However …

Fibromyalgia is the currently preferred term for widespread musculoskeletal pain, typically
accompanied by other symptoms such as fatigue, memory problems, and sleep and mood …