Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

Studies in invertebrates have led to the identification of a number of genes that regulate
lifespan, some of which encode components of the insulin or insulin-like signalling …

This investigation compared the effect of high‐volume (VOL) versus high‐intensity (INT)
resistance training on stimulating changes in muscle size and strength in resistance‐trained …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

Many male animals wield ornaments or weapons of exaggerated proportions. We propose
that increased cellular sensitivity to signaling through the insulin/insulin-like growth factor …

In the last ten years, we have made considerable progress in our genetic and molecular
understanding of all aspects of skeletal development, chondrogenesis, joint formation, and …

Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …