[HTML][HTML] Unlocking the promise of mRNA therapeutics
E Rohner, R Yang, KS Foo, A Goedel… - Nature biotechnology, 2022 - nature.com
The extraordinary success of mRNA vaccines against coronavirus disease 2019 (COVID-19)
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
has renewed interest in mRNA as a means of delivering therapeutic proteins. Early clinical …
[HTML][HTML] Stem cell therapy: from idea to clinical practice
M Mousaei Ghasroldasht, J Seok, HS Park… - International journal of …, 2022 - mdpi.com
Regenerative medicine is a new and promising mode of therapy for patients who have
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …
limited or no other options for the treatment of their illness. Due to their pleotropic therapeutic …
[PDF][PDF] Heart regeneration: 20 years of progress and renewed optimism
JC Garbern, RT Lee - Developmental cell, 2022 - cell.com
Cardiovascular disease is a leading cause of death worldwide, and thus there remains great
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …
interest in regenerative approaches to treat heart failure. In the past 20 years, the field of …
Advances of engineered extracellular vesicles-based therapeutics strategy
H Komuro, S Aminova, K Lauro… - Science and Technology …, 2022 - Taylor & Francis
Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-
bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and …
bound vesicles which encapsulate bioactive molecules, such as nucleic acids, proteins, and …
An injectable alginate/fibrin hydrogel encapsulated with cardiomyocytes and VEGF for myocardial infarction treatment
C Liu, Y Wu, H Yang, K Lu, H Zhang, Y Wang… - Journal of Materials …, 2023 - Elsevier
Myocardial infarction (MI) is one of the typical cardiovascular diseases, which persist as the
leading cause of death globally. Due to the poor regenerative capability of endogenous …
leading cause of death globally. Due to the poor regenerative capability of endogenous …
Adoptive cell therapy for cancer treatment
Adoptive cell therapy (ACT) is a rapidly growing anti‐cancer strategy that has shown
promise in treating various cancer types. The concept of ACT involves activating patients' …
promise in treating various cancer types. The concept of ACT involves activating patients' …
[HTML][HTML] Matrix metalloproteases from adipose tissue-derived stromal cells are spatiotemporally regulated by hydrogel mechanics in a 3D microenvironment
FD Martinez-Garcia, JA van Dongen, JK Burgess… - Bioengineering, 2022 - mdpi.com
Adipose tissue-derived stromal cells (ASCs) are of interest in tissue engineering and
regenerative medicine (TERM) due to their easy acquisition, multipotency, and secretion of a …
regenerative medicine (TERM) due to their easy acquisition, multipotency, and secretion of a …
Engineering stem cell therapeutics for cardiac repair
J Fang, JJ Li, X Zhong, Y Zhou, RJ Lee… - Journal of Molecular and …, 2022 - Elsevier
Cardiovascular disease is the leading cause of death in the world. Stem cell-based
therapies have been widely investigated for cardiac regeneration in patients with heart …
therapies have been widely investigated for cardiac regeneration in patients with heart …
[HTML][HTML] CSF2RB overexpression promotes the protective effects of mesenchymal stromal cells against ischemic heart injury
T Qi, X Xu, Y Guo, Y Xia, L Peng, C Li, F Ding, C Gao… - Theranostics, 2023 - ncbi.nlm.nih.gov
Aims: The invasive intramyocardial injection of mesenchymal stromal cells (MSCs) allows for
limited repeat injections and shows poor therapeutic efficacy against ischemic heart failure …
limited repeat injections and shows poor therapeutic efficacy against ischemic heart failure …
[HTML][HTML] Bioengineering for vascularization: Trends and directions of photocrosslinkable gelatin methacrylate hydrogels
Gelatin methacrylate (GelMA) hydrogels have been widely used in various biomedical
applications, especially in tissue engineering and regenerative medicine, for their excellent …
applications, especially in tissue engineering and regenerative medicine, for their excellent …