The molecular details involved in the folding, dynamics, organization, and interaction of
proteins with other molecules are often difficult to assess by experimental techniques …

The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …

Scramblases play a pivotal role in facilitating bidirectional lipid transport across cell
membranes, thereby influencing lipid metabolism, membrane homeostasis, and cellular …

Mitochondria are double-membrane-bounded organelles that depend critically on
phospholipids supplied by the endoplasmic reticulum. These lipids must cross the outer …

White adipocytes function as major energy reservoirs in humans by storing substantial
amounts of triglycerides, and their dysfunction is associated with metabolic disorders; …

Over the past two decades, we have witnessed a growing appreciation for the importance of
membrane contact sites (CS) in facilitating direct communication between organelles. CS …

Fusion of the outer mitochondrial membrane (OMM) is regulated by mitofusin 1 (MFN1) and
2 (MFN2), yet the differential contribution of each of these proteins is less understood …

Abstract Mitochondrial carrier homolog 2 (MTCH2) is a member of the solute carrier 25
family, located on the outer mitochondrial membrane. MTCH2 was first identified in 2000 …

Simple Summary Scramblases are proteins that translocate phospholipids from one leaflet
of a membrane bilayer to the other. Our work identifies that a well-characterized protein from …

Mitochondrial carrier homolog 2 (MTCH2) is currently one of the most enigmatic
mitochondrial proteins. MTCH2's ligand is the pro-apoptotic BID protein, and the love story …