Publisher Summary Studies of cytotoxicity by human lymphocytes revealed not only that
both allogeneic and syngeneic tumor cells were lysed in a non-MHC-restricted fashion, but …

Following primary infection, human cytomegalovirus (HCMV) establishes lifelong latency
and periodically reactivates without causing symptoms in healthy individuals. In the absence …

Viral infection outcomes are sex biased, with males generally more susceptible than
females. Paradoxically, the numbers of antiviral natural killer (NK) cells are increased in …

Natural killer (NK) cells belong to the innate immune system; they can control virus infections
and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of …

Natural killer (NK) cells play critical roles defending against tumors and pathogens. We
show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to …

In an adaptive immune response, naive T cells proliferate during infection and generate long-
lived memory cells that undergo secondary expansion after a repeat encounter with the …

Virologic and immunologic studies were performed on five patients presenting with primary
human immunodeficiency virus type 1 (HIV-1) infection. CD8+ cytotoxic T lymphocyte (CTL) …

▪ Abstract NK cells are regulated by opposing signals from receptors that activate and inhibit
effector function. While positive stimulation may be initiated by an array of co-stimulatory …

ATURAL KILLER (NK) cells comprise 10% to 15% N of human peripheral blood
lymphocytes (PBL) and most have the morphology of large granular lymphocytes (LGL).'s2 …

Natural killer cells are innate immune cells that control certain microbial infections and
tumours. The function of natural killer cells is regulated by a balance between signals …