Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly
40000 patients died from the disease in the United States. Pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal
clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells …

Pancreatic stellate cell (PSC) is a type of pluripotent cell located between pancreatic lobules
and the surrounding area of acinars. When activated, PSC can be transformed into …

Improved understanding of the role of PSCs in pancreatic pathophysiology has prompted a
focus on translational studies aimed at developing novel approaches to modulate PSC …

The prevalence of diabetes mellitus (DM) and acute pancreatitis (AP) increases
continuously, therefore, to understand the effects of preexisting diabetes on AP is crucially …

The clinical significance of diabetes arising in the setting of pancreatic disease (also known
as diabetes of the exocrine pancreas, DEP) has drawn more attention in recent years …

Pancreatic stellate cells play a pivotal role in the development of pancreatic fibrosis. A wide
variety of external stimuli can cause PSC activation accompanied by metabolic changes …

Epidemiological studies support strong links between obesity, diabetes, and pancreatic
disorders including pancreatitis and pancreatic adenocarcinoma (PDAC). Type 2 diabetes …

Uncontrolled scarring, or fibrosis, can interfere with the normal function of virtually all tissues
of the body, ultimately leading to organ failure and death. Fibrotic diseases represent a …

Pancreatic stellate cells (PSCs) play a central role as source of fibrogenic cells in pancreatic
cancer and chronic pancreatitis. In contrast to quiescent hepatic stellate cells (qHSCs), a …