Although heart failure due to a wide variety of pathological stimuli including myocardial
infarction, pressure overload and volume overload is associated with cardiac hypertrophy …

Cathepsin B (CTSB), a lysosomal cysteine protease, plays an important role in human
physiology and pathology. CTSB is associated with various human diseases, and its …

The proteasome, the primary protease for ubiquitin-dependent proteolysis in eukaryotes, is
usually found as a mixture of 30S, 26S, and 20S complexes. These complexes have …

Objectives: This study sought to investigate the hypothesis that the favorable effects of
mesenchymal stromal cells (MSCs) on infarct repair are mediated by macrophages …

Key points Although doxorubicin is a highly effective anti‐tumour agent, the administration of
this drug is associated with significant side effects, including contractile dysfunction and …

Calpains are cytosolic calcium-activated cysteine proteases. Recently, they have been
proposed to influence signal transduction processes leading to myocardial remodelling and …

Cathepsin B (CTSB), a member of the lysosomal cathepsin family that is expressed in both
murine and human hearts, was previously shown to participate in apoptosis, autophagy, and …

As cardiomyocytes have a limited capability for proliferation, renewal, and repair, the loss of
heart cells followed by replacement with fibrous tissue is considered to result in the …

The more than 300 currently identified post-translational modifications (PTMs) provides
great scope for subtle or dramatic alteration of protein structure and function. Furthermore …

The dystrophin-glycoprotein complex (DGC), situated at the sarcolemma dynamically
remodels during cardiac disease. This review examines DGC remodeling as a common …