Ethnobotany and the role of plant natural products in antibiotic drug discovery

G Porras, F Chassagne, JT Lyles, L Marquez… - Chemical …, 2020 - ACS Publications
The crisis of antibiotic resistance necessitates creative and innovative approaches, from
chemical identification and analysis to the assessment of bioactivity. Plant natural products …

Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Biologically active isoquinoline alkaloids covering 2014–2018

XF Shang, CJ Yang… - Medicinal research …, 2020 - Wiley Online Library
Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have
attracted considerable attention from researchers worldwide since the early 19th century …

Quinoline and its derivatives as corrosion inhibitors: a review

C Verma, MA Quraishi, EE Ebenso - Surfaces and Interfaces, 2020 - Elsevier
Quinoline is a nitrogenous bicyclic heterocyclic compound with molecular formula of C 9 H 7
N in which pyridine moiety is fused with benzene ring. Quinoline and its derivatives are …

Dual inhibitors of human DNA topoisomerase II and other cancer-related targets

Z Skok, N Zidar, D Kikelj, J Ilaš - Journal of medicinal chemistry, 2019 - ACS Publications
Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …

Biosynthesis investigations of terpenoid, alkaloid, and flavonoid antimicrobial agents derived from medicinal plants

W Huang, Y Wang, W Tian, X Cui, P Tu, J Li, S Shi… - Antibiotics, 2022 - mdpi.com
The overuse of antibiotics in the past decades has led to the emergence of a large number
of drug-resistant microorganisms. In recent years, the infection rate caused by multidrug …

Bacterial terpenome

JD Rudolf, TA Alsup, B Xu, Z Li - Natural product reports, 2021 - pubs.rsc.org
Covering: up to mid-2020 Terpenoids, also called isoprenoids, are the largest and most
structurally diverse family of natural products. Found in all domains of life, there are over 80 …

Quinazoline-based VEGFR-2 inhibitors as potential anti-angiogenic agents: A contemporary perspective of SAR and molecular docking studies

M Moradi, A Mousavi, Z Emamgholipour… - European Journal of …, 2023 - Elsevier
Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …

Therapeutic progression of quinazolines as targeted chemotherapeutic agents

R Bansal, A Malhotra - European Journal of Medicinal Chemistry, 2021 - Elsevier
Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …

Synthetic and medicinal perspective of quinolines as antiviral agents

R Kaur, K Kumar - European Journal of Medicinal Chemistry, 2021 - Elsevier
In current scenario, various heterocycles have come up exhibiting crucial role in various
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …