[HTML][HTML] Targeting IL-6 trans-signalling: past, present and future prospects
S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …
Interleukin-6 cytokine: An overview of the immune regulation, immune dysregulation, and therapeutic approach
Several studies have shown that interleukin 6 (IL-6) is a multifunctional cytokine with both
pro-inflammatory and anti-inflammatory activity, depending on the immune response …
pro-inflammatory and anti-inflammatory activity, depending on the immune response …
The advent of immune stimulating CAFs in cancer
M Tsoumakidou - Nature Reviews Cancer, 2023 - nature.com
The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …
prevailed throughout the past decade. However, recent high-throughput, high-resolution …
[HTML][HTML] Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19
C Matsumoto, S Shibata, T Kishi, S Morimoto… - Hypertension …, 2023 - nature.com
Abstracts The coronavirus disease 2019 (COVID-19) affects infected patients even after the
acute phase and impairs their health and quality of life by causing a wide variety of …
acute phase and impairs their health and quality of life by causing a wide variety of …
[HTML][HTML] Central roles of STAT3-mediated signals in onset and development of cancers: tumorigenesis and immunosurveillance
S Hashimoto, A Hashimoto, R Muromoto, Y Kitai… - Cells, 2022 - mdpi.com
Since the time of Rudolf Virchow in the 19th century, it has been well-known that cancer-
associated inflammation contributes to tumor initiation and progression. However, it remains …
associated inflammation contributes to tumor initiation and progression. However, it remains …
Structure of the IL-27 quaternary receptor signaling complex
Abstract Interleukin 27 (IL-27) is a heterodimeric cytokine that functions to constrain T cell-
mediated inflammation and plays an important role in immune homeostasis. Binding of IL-27 …
mediated inflammation and plays an important role in immune homeostasis. Binding of IL-27 …
[HTML][HTML] Perspectives of JAK inhibitors for large vessel vasculitis
R Watanabe, M Hashimoto - Frontiers in Immunology, 2022 - frontiersin.org
Vasculitis is an inflammation of the blood vessels caused by autoimmunity and/or
autoinflammation, and recent advances in research have led to a better understanding of its …
autoinflammation, and recent advances in research have led to a better understanding of its …
Gp130–HIF1α axis–induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling
S Kang, S Onishi, Z Ling, H Inoue… - Proceedings of the …, 2024 - National Acad Sciences
Protection against endothelial damage is recognized as a frontline approach to preventing
the progression of cytokine release syndrome (CRS). Accumulating evidence has …
the progression of cytokine release syndrome (CRS). Accumulating evidence has …
[HTML][HTML] Targeting cytokine and chemokine signaling pathways for cancer therapy
M Yi, T Li, M Niu, H Zhang, Y Wu, K Wu… - Signal Transduction and …, 2024 - nature.com
Cytokines are critical in regulating immune responses and cellular behavior, playing dual
roles in both normal physiology and the pathology of diseases such as cancer. These …
roles in both normal physiology and the pathology of diseases such as cancer. These …
Roles of RNA-binding proteins in immune diseases and cancer
S Hashimoto, T Kishimoto - Seminars in cancer biology, 2022 - Elsevier
Genetic information that is transcribed from DNA to mRNA, and then translated from mRNA
to protein, is regulated by complex and sophisticated post-transcriptional mechanisms …
to protein, is regulated by complex and sophisticated post-transcriptional mechanisms …