Lung cancer is a major cause of death worldwide, being often detected at a later stage due
to the non-appearance of early symptoms. Therefore, specificity of the treatment is of utmost …

Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers
comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is …

Background Rearranged during transfection (RET) rearrangement has been identified as
one of the crucial oncogenic drivers in non-small cell lung cancer (NSCLC). Recently, two …

NADH/NAD+ redox balance is pivotal for cellular metabolism. Systematic identification of
NAD (H) redox regulators, although currently lacking, would help uncover unknown effectors …

Cancer onset and progression are known to be regulated by genetic and epigenetic events,
including RNA modifications (aka epitranscriptomics). So far, more than 150 chemical …

Tumor heterogeneity is the major factor for inducing drug resistance. p53 is the major
defender to maintain genomic stability, which is a high proportion mutated in most of the …

This study analyzed whether extended molecular profiling can predict the development of
epidermal growth factor receptor (EGFR) gene T790M mutation, which is the most frequent …

Accurate prognostic markers are essential for guiding effective lung cancer treatment
strategies. The level of 5-hydroxymethylcytosine (5hmC) in tissue is independently …

Introduction The current standard of care of locally advanced non-small cell lung cancer (LA-
NSCLC) is concurrent chemoradiation, followed by consolidation durvalumab. However …

Lung cancer is a highly aggressive neoplasm and, despite the development of recent
therapies, tumor progression and recurrence following the initial response remains …