The ability of glucocorticoids (GC) to efficiently kill lymphoid cells has led to their inclusion in
essentially all chemotherapy protocols for lymphoid malignancies. This review summarizes …

Glucocorticoids (GCs) induce programmed cell death with the morphologic characteristics of
apoptosis in cells of the lymphoid lineage at certain stages of differentiation. Although the …

Many chemotherapeutic agents induce mitochondrial-membrane disruption to initiate
apoptosis. However, the upstream events leading to drug-induced mitochondrial …

ABSTRACT We report that resveratrol (3, 5, 4′‐trihydroxy‐trans‐stilbene), a phytoalexin
found in grapes and other plant food, induced a breakdown of the mitochondrial …

The study aimed to assess the effects of polyphenols when used in combination with
doxorubicin and etoposide, and to determine whether polyphenols sensitised leukaemia …

Background Daunorubicin is used clinically in the treatment of myeloma, acute lymphatic
and myelocytic leukaemia. The toxic lesions caused by daunorubicin induce various modes …

The histone deacetylase inhibitor and potential anti‐cancer drug sodium butyrate is a
general inducer of growth arrest, differentiation, and in certain cell types, apoptosis. In …

Activation of p53 induces apoptosis in various cell types. However, the mechanism by which
p53 induces apoptosis is still unclear. We reported previously that the activation of a …

Cycloheximide (CHX) can contribute to apoptotic processes, either in conjunction with
another agent (eg tumor necrosis factor-α) or on its own. However, the basis of this CHX …

Background: Mortality rates for leukemia are high despite considerable improvements in
treatment. Since polyphenols exert pro-apoptotic effects in solid tumors, our study …