Mass spectrometry approaches to glycomic and glycoproteomic analyses

LR Ruhaak, G Xu, Q Li, E Goonatilleke… - Chemical …, 2018 - ACS Publications
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …

Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry

C Giesen, HAO Wang, D Schapiro, N Zivanovic… - Nature …, 2014 - nature.com
Mass cytometry enables high-dimensional, single-cell analysis of cell type and state. In
mass cytometry, rare earth metals are used as reporters on antibodies. Analysis of metal …

Quantitative mass spectrometry imaging of biological systems

D Unsihuay, D Mesa Sanchez… - Annual review of physical …, 2021 - annualreviews.org
Mass spectrometry imaging (MSI) is a powerful, label-free technique that provides detailed
maps of hundreds of molecules in complex samples with high sensitivity and subcellular …

High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives

S Ma, Y Leng, X Li, Y Meng, Z Yin, W Hang - TrAC Trends in Analytical …, 2023 - Elsevier
Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research

JL Norris, RM Caprioli - Chemical reviews, 2013 - ACS Publications
Human beings are adept at discerning relevant information from complex systems by
processing visual information. Similarly, as scientists labor to understand the fundamental …

MassBank: a public repository for sharing mass spectral data for life sciences

H Horai, M Arita, S Kanaya, Y Nihei… - Journal of mass …, 2010 - Wiley Online Library
MassBank is the first public repository of mass spectra of small chemical compounds for life
sciences (< 3000 Da). The database contains 605 electron‐ionization mass spectrometry (EI …

[HTML][HTML] The emergence of peptides in the pharmaceutical business: From exploration to exploitation

T Uhlig, T Kyprianou, FG Martinelli, CA Oppici… - EuPA open …, 2014 - Elsevier
This minireview touches upon the challenges and opportunities peptides experience on the
track to become an approved pharmaceutical. Peptide attributes originally considered …

Peak learning of mass spectrometry imaging data using artificial neural networks

WM Abdelmoula, BGC Lopez, EC Randall… - Nature …, 2021 - nature.com
Mass spectrometry imaging (MSI) is an emerging technology that holds potential for
improving, biomarker discovery, metabolomics research, pharmaceutical applications and …

Mass spectrometry‐based plant metabolomics: Metabolite responses to abiotic stress

TF Jorge, JA Rodrigues, C Caldana… - Mass spectrometry …, 2016 - Wiley Online Library
Metabolomics is one omics approach that can be used to acquire comprehensive
information on the composition of a metabolite pool to provide a functional screen of the …