Magnetic resonance imaging (MRI) is a clinical imaging modality effective for anatomical
and functional imaging of diseased soft tissues, including solid tumors. MRI contrast agents …

Magnetism in medicine has had a long and interesting history. In the 10th century AD,
Egyptian physician and philosopher Avicenna prescribed a grain of magnetite dissolved in …

The microvascular network formed by the capillaries supplies the tissues and permits their
function. It provides a considerable surface area for exchanges between blood and tissues …

Gadolinium-based MRI contrast agents (CAs) can be effective at a∼ 100-fold lower
concentration of Gadolinium ions in comparison to the concentration of Iodine atoms …

I. General remarks 173 II. Contribution to the relaxivity 176 A. Inner-sphere contribution to
the relaxivity 178 B. Outer-sphere contribution to the relaxivity 184 C. Second-sphere …

Focused ultrasound (FUS) combined with a circulating microbubble agent is a promising
strategy to non-invasively disrupt the blood–brain barrier (BBB) and could enable targeted …

Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier
(BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with …

In the recent years Magnetic Resonance Imaging has evolved into one of the most powerful
diagnostic techniques in medicine, in part thanks to the application of suitable contrast …

The incorporation of metal complexes into polymers leads to functional materials; whereas,
the properties of polymers–easy processability, light weight or the adjustable molar mass …

Stable gadolinium chelates are widely used as the contrast agents (CAs) for magnetic
resonance imaging (MRI). Conjugation of the chelates onto macromolecular carriers forms …