The molecular interactions underlying regulation of the immune response take place in a
nanoscale gap between T cells and antigen-presenting cells, termed the immunological …

Cancer poses a serious health problem in society and is increasingly surpassing
cardiovascular disease as the leading cause of mortality in the United States. Current …

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease characterized by
an extensive fibroinflammatory stroma, which includes abundant cancer-associated …

Summary Background Before February, 2021, there was no standard treatment regimen for
locally advanced basal cell carcinoma after first-line hedgehog inhibitor (HHI) therapy …

GSDMD is a recently discovered pyroptosis executioner in monocytes whose N-terminal
domain can insert into the inner leaflet of cell membranes and form extensive pores …

Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with
infected or transformed target cells and then secreting cytotoxic perforin and granzyme into …

Cytotoxic T lymphocytes (CTLs) kill virus-infected and tumour cells with remarkable
specificity. Upon recognition, CTLs form a cytolytic immune synapse with their target cell …

Over the past two decades, the secreted protein sonic hedgehog (SHH) has emerged as a
critical morphogen during embryonic lung development, regulating the interaction between …

Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer related
death. The urgent need for effective therapies is highlighted by the lack of adequate …

Current cancer therapies target the bulk of the tumour, while a population of highly resistant
tumour cells may be able to repopulate the tumour and metastasize to new sites. Cancer …